Kinetic folding mechanism of PDZ2 from PTP-BL
نویسندگان
چکیده
منابع مشابه
Kinetic folding mechanism of PDZ2 from PTP-BL.
PDZ domains represent a large family of protein-interaction modules associated with a variety of unrelated proteins with different functions. We report a complete characterization of the kinetic folding mechanism of a fluorescent variant of PDZ2 from PTP-BL, investigated under a variety of different experimental conditions. For this purpose, we engineered a fluorescent variant of this protein Y...
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The insulin/insulin-like growth factor 1 (IGF-1) signaling pathway is a major regulator of adipose tissue growth and differentiation. We recently demonstrated that human protein tyrosine phosphatase (PTP) L1, a large cytoplasmic phosphatase also known as PTP-BAS/PTPN13/PTP-1E, is a negative regulator of IGF-1R/IRS-1/Akt pathway in breast cancer cells. This triggered us to investigate the potent...
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ژورنال
عنوان ژورنال: Protein Engineering, Design and Selection
سال: 2005
ISSN: 1741-0134,1741-0126
DOI: 10.1093/protein/gzi047